◎ Investigational

Claseprubart (DNTH103)

1
Evidence entries
1
Clinical trials
Overview
Treatment Details
Mechanism of Action
Monoclonal antibody targeting complement C1s, blocking the classical complement pathway. Engineered with YTE half-life extension for infrequent subcutaneous self-administration.
Dosing Notes
Investigational; subcutaneous dosing every 2 weeks in current trial.
Treatment Type
pharmaceutical
Clinical Evidence
What the Evidence Shows
Each finding below is linked to its primary source. Confidence levels reflect the quality and quantity of available evidence — not CelluTarget's endorsement of any treatment.
High: Supported by multiple robust studies or regulatory approval
Moderate: Supported by limited controlled studies or consistent case series
Low: Based on case reports, expert opinion, or early-phase data only
Low ConfidenceBased on case reports, expert opinion, or early-phase data only
Phase 2 MoMeNtum trial ongoing; targets classical complement pathway via C1s inhibition; top-line results expected Q4 2026.
Verified Jul 2026
Clinical Trial Registry
MoMeNtum: Phase 2 trial of DNTH103 (claseprubart) in adults with MMN — NCT06537999
Published September 2025
View source ↗
Clinical Trials
Linked Trials1 trial